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Consultancy
Services
BioTarget
Consulting provides research and preclinical development expertise to
enable the efficient translation of biotechnology discoveries into
commerically viable development projects. The scope of the
consultancy is broad and encompasses the following research and
development areas:
Discovery
Research
- Pharmaceutical discovery program
assessment -
tractability, commercial rationale, medical need, ease of development
- Drug screening cascade development -
decision
points, criteria setting, hit to lead to development candidate planning
- In
vitro and in
vivo model assessment and development
- Gantt charting progress against
milestones and
targets
- Pharmacology consulting -
neuropharmacology and
molecular pharmacology specialist
- Disease
target consulting - considerable expertise in psychiatry,
autism-spectrum disorders, stroke, TBI, neurodegenerative disorders,
obesity, diabetes, oncology, wound-healing and others
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Preclinical
Development
- Early stage preclincal planning
- Off-target screening
- ADME studies - in vitro and in vivo
pharmacokinetics (PK), PK-PD correlations, CYP enzyme screening,
stability screens
- Genotoxicity advice and contracting -
Ames,
chromosomal abberrations, micronucleus testing
- Secondary pharmacology safety testing -
e.g.
cardiovasular and respiratory studies required by regulators
- GLP safety and GLP toxicology - studies
required by ICH / FDA / EMEA Guidance
- Guidance on CMC requirements for drug
substance
manufacture to GMP
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